Biomaterials Research

Biomaterials research is directed mainly toward surface derivatization and coating to impart biocompatibility and therapeutic function to implantable devices. For example, bacterial adhesion and infection at the site of an implant can be a critical problem following surgery and endovascular intervention. Thrombosis at the site of an implant or extracorporeal device is a critical problem as well. Biomaterials researchers are engaged in design and synthesis of surface active, bioactive copolymer constructs that can be immobilized at interfaces such that the mobility, solvent accessibility and activity of therapeutic components are preserved. Other work includes quantifying specific factors governing the spatial and temporal arrangement of such constructs at interfaces, covalent surface derivatization with bioactive molecules, and basic and applied studies of biopolymer structure and function at natural and synthetic surfaces. In vitro function of novel coatings and devices is evaluated with a focus on anticoagulant activity, and antimicrobial activity against clinically relevant bacteria. Material function is evaluated in vivo as well, in cooperation with researchers in the OSU College of Veterinary Medicine, using any of several animal models of human disease approved for this purpose.

Faculty:  McGuire, Rochefort