Synthetic Replacements for Synovial Fluid for Knee Joint Lubrication

By:
Marie Peroutka and Alia Mulder

Mentors:
Tarek Fadel and Katie Vollmert

Faculty:
Dr. Skip Rochefort

Synovial fluid cushions and lubricates the synvoial joints of the human body, such as the knee. The biopolyelectrolyte known as hyaluronic acid is the component of synovial fluid primarily responsible for its rheological properties; however, this polymer is degraded in cases of advanced osteoarthritis, resulting in increased wear and tear on the knee. A synthetic replacement for hyaluronic acid, possibly composed of naturally-occurring gums, would be a cost effective way to restore rheological stability to the joint.